Lake Titicaca is a lake located on the border of Bolivia and Peru. It sits 3,812 m (12,500 ft) above sea level, making it one of the highest commercially navigable lakes in the world. It is the largest lake in South America.
In the episode "Black Buddha, Pt. Two", Javier Vachon and the Inca recount the story of how they were brought across, Vachon telling his side to Tracy Vetter, and the Inca telling his to Nick Knight. According to Vachon, who, in his mortal life, had been a conquistador with Pizarro's forces, the Spanish were in the hills near Lake Titicaca preparing for battle with the army of the Inca. He was sent for reinforcements, but was followed and waylaid by an enemy warrior. When both were mortally wounded, they were brought over by an unnamed South American vampire.
There is some reason to doubt the details of Vachon's story, since in 1531 the Spanish forces were nowhere near Lake Titicaca.
The origin of the name "Titicaca" is unknown. It has been translated as "Rock Puma", allegedly because of its resemblance to the shape of a puma hunting a rabbit, combining words from the local languages Quechua and Aymara. However, it has also been translated as "Crag of Lead." Locally, the lake goes by several names.